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Evolutionary comparison of CTCF and YY1 binding in primate lymphoblastoid cell lines

ABSTRACT: We performed an evolutionary comparison of the binding of the TF CTCF in human, chimpanzee, gorilla, orang-utan, macaque, baboon and marmoset using lymphoblastoid cell lines (LCLs). We also probes YY1 binding in human, chimpanzee, orang-utan and baboon LCLs as well as human and mouse liver.

ORGANISM(S): Pan troglodytes

SUBMITTER: Petra Catalina Schwalie

PROVIDER: E-MTAB-1511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes.

Schwalie Petra C PC Ward Michelle C MC Cain Carolyn E CE Faure Andre J AJ Gilad Yoav Y Odom Duncan T DT Flicek Paul P

Genome biology 20131231 12

<h4>Background</h4>The genomic binding of CTCF is highly conserved across mammals, but the mechanisms that underlie its stability are poorly understood. One transcription factor known to functionally interact with CTCF in the context of X-chromosome inactivation is the ubiquitously expressed YY1. Because combinatorial transcription factor binding can contribute to the evolutionary stabilization of regulatory regions, we tested whether YY1 and CTCF co-binding could in part account for conservatio ...[more]

PMID: 24380390

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