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Blood analysis reveals differences in innate inflammatory sensitivity between species

ABSTRACT: Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from rabbit, pig, sheep, cow, chimpanzee, human, mice, rats, baboon, and rhesus.

ORGANISM(S): Bos taurus Rattus norvegicus Mus musculus Pan troglodytes Sus scrofa Homo sapiens Macaca Oryctolagus cuniculus Papio anubis Ovis aries

PROVIDER: GSE249010 | GEO | 2025/01/02

REPOSITORIES: GEO

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