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Clonal heterogeneity in melanoma

ABSTRACT: Genetic heterogeneity is an important feature of solid tumors, however it is often assumed that most cancer cell lines are genetically homogeneous. A disparity in genetic complexity between cell lines and the disease they model could result in problems such as in vitro preclinical experiments overstating the effectiveness of putative therapeutics. We therefore derived clonal sublines by single cell cloning of in house derived early passage melanoma cell lines (LM-MEL-series), and compared their genomes to each other and the parental cell line using Illumina 610-Quad SNP arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Anaka 

PROVIDER: E-MTAB-1753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors.

Anaka Matthew M   Hudson Christopher C   Lo Pu-Han PH   Do Hongdo H   Caballero Otavia L OL   Davis Ian D ID   Dobrovic Alexander A   Cebon Jonathan J   Behren Andreas A  

BMC medical genomics 20131011

<h4>Background</h4>Intratumoral heterogeneity is a major obstacle for the treatment of cancer, as the presence of even minor populations that are insensitive to therapy can lead to disease relapse. Increased clonal diversity has been correlated with a poor prognosis for cancer patients, and we therefore examined genetic, transcriptional, and functional diversity in metastatic melanoma.<h4>Methods</h4>Amplicon sequencing and SNP microarrays were used to profile somatic mutations and DNA copy numb  ...[more]

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