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Transcription profiling of two mesothelioma cell lines (MPP89 and REN), and of HMC-TERT non tumoral mesothelial cells

ABSTRACT: miRNA profile analysis of two mesothelioma cell lines (MPP89 and REN), and of HMC-TERT non tumoral mesothelial cells

ORGANISM(S): Homo sapiens

SUBMITTER: Giovanni Gaudino 

PROVIDER: E-MEXP-1699 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications.

Busacca Sara S   Germano Serena S   De Cecco Loris L   Rinaldi Maurizio M   Comoglio Federico F   Favero Francesco F   Murer Bruno B   Mutti Luciano L   Pierotti Marco M   Gaudino Giovanni G  

American journal of respiratory cell and molecular biology 20090605 3

MicroRNAs (miRNAs) post-transcriptionally regulate the expression of target genes, and may behave as oncogenes or tumor suppressors. Human malignant mesothelioma is an asbestos-related cancer, with poor prognosis and low median survival. Here we report, for the first time, a cross-evaluation of miRNA expression in mesothelioma (MPP-89, REN) and human mesothelial cells (HMC-telomerase reverse transcriptase). Microarray profiling, confirmed by real-time quantitative RT-PCR, revealed a differential  ...[more]

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