Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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CpBV-H4 ChIP-Seq


ABSTRACT: To address a target gene spectrum of CpBV-H4, we need to analyze total gene expression in response to a specific expression of CpBV-H4 by a transient expression technique.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Tribolium castaneum

SUBMITTER: Rahul Hepat 

PROVIDER: E-MTAB-1835 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A viral histone h4 joins to eukaryotic nucleosomes and alters host gene expression.

Hepat Rahul R   Song Ji-Joon JJ   Lee Daeweon D   Kim Yonggyun Y  

Journal of virology 20130807 20


A viral histone H4 (CpBV-H4) is encoded in a polydnavirus, Cotesia plutellae bracovirus. Its predicted amino acid sequence is highly homologous to that of host insect histone H4 except for an extended N-terminal tail containing 38 amino acids with nine lysine residues. Its expression induces an immunosuppression of target insects by suppressing immune-associated genes, presumably through an epigenetic control. This study analyzed its molecular interaction with eukaryotic host nucleosomes and sub  ...[more]

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