Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Mesenchyme Of Mammary Gland, Cell Culture
DISEASE(S): Triple-receptor Negative Breast Cancer
SUBMITTER: Matthew Holt
LAB HEAD: Nicolas L. Young
PROVIDER: PXD013766 | Pride | 2019-11-22
REPOSITORIES: Pride
Action | DRS | |||
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Full_proteoform_allruns.csv | Csv | |||
SUM159_But_5mM_4h_H4_1_1.raw | Raw | |||
SUM159_But_5mM_4h_H4_1_2.raw | Raw | |||
SUM159_But_5mM_4h_H4_1_3.raw | Raw | |||
SUM159_But_5mM_4h_H4_2_1.raw | Raw |
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Journal of the American Society for Mass Spectrometry 20191118 12
Proteins physiologically exist as "proteoforms" that arise from one gene and acquire additional function by post-translational modifications (PTM). When multiple PTMs coexist on single protein molecules, top-down proteomics becomes the only feasible method of characterization; however, most top-down methods have limited quantitative capacity and insufficient throughput to truly address proteoform biology. Here we demonstrate that top-down proteomics can be quantitative, reproducible, sensitive, ...[more]