The Peptide Semax Affects the Expression of Genes Related to the Immune and Vascular Systems in Rat Brain Focal Ischemia: Genome-wide Transcriptional Analysis
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Ekaterina Medvedeva
PROVIDER: E-MTAB-1864 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
Medvedeva Ekaterina V EV Dmitrieva Veronika G VG Povarova Oksana V OV Limborska Svetlana A SA Skvortsova Veronika I VI Myasoedov Nikolay F NF Dergunova Lyudmila V LV
BMC genomics 20140324
<h4>Background</h4>The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke; however, the molecular mechanisms underlying its action remain obscure. Our genome-wide study was designed to investigate the response of the transcriptome of ischemized rat brain cortex tissues to the action of Semax in vivo.<h4>Results</h4>The gene-expression alteration caused by the action of the peptide Semax was compared with the gene expression o ...[more]
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