Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer IIx, Illumina HiSeq 2000
ORGANISM(S): Homo sapiens
SUBMITTER: Helena Kilpinen
PROVIDER: E-MTAB-1884 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kilpinen Helena H Waszak Sebastian M SM Gschwind Andreas R AR Raghav Sunil K SK Witwicki Robert M RM Orioli Andrea A Migliavacca Eugenia E Wiederkehr Michaël M Gutierrez-Arcelus Maria M Panousis Nikolaos I NI Yurovsky Alisa A Lappalainen Tuuli T Romano-Palumbo Luciana L Planchon Alexandra A Bielser Deborah D Bryois Julien J Padioleau Ismael I Udin Gilles G Thurnheer Sarah S Hacker David D Core Leighton J LJ Lis John T JT Hernandez Nouria N Reymond Alexandre A Deplancke Bart B Dermitzakis Emmanouil T ET
Science (New York, N.Y.) 20131017 6159
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coo ...[more]