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Transcription profiling of Anopheles gambiae midgut and fat bodies 1 and 11 days post Plasmodium berghei infection to investigate responses in detoxification genes


ABSTRACT: Detoxification genes were assayed for their response to Plasmodium berghei infection at 1 and 11 days post infection in Anopheles gambiae mosquitoes.

ORGANISM(S): Anopheles gambiae

DISEASE(S): uninfected 11dpi

SUBMITTER: Rute FŽlix 

PROVIDER: E-MTAB-195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Plasmodium infection alters Anopheles gambiae detoxification gene expression.

Félix Rute C RC   Müller Pie P   Ribeiro Vera V   Ranson Hilary H   Silveira Henrique H  

BMC genomics 20100519


<h4>Background</h4>Anopheles gambiae has been shown to change its global gene expression patterns upon Plasmodium infection. While many alterations are directly related to the mosquito's innate immune response, parasite invasion is also expected to generate toxic by-products such as free radicals. The current study aimed at identifying which loci coding for detoxification enzymes are differentially expressed as a function of Plasmodium berghei infection in midgut and fat body tissues.<h4>Results  ...[more]

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