Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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SyangRNAseq

ABSTRACT: Gene expression was studied in the presence or absence of Otx2 (RNAi) in the Rex1GFPd2 mouse embryonic stem cell line (parental line; E14Tg2a) in undifferentiated and differentiated states.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Mus musculus

SUBMITTER: Leo Leo Zeef 

PROVIDER: E-MTAB-2245 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency.

Yang Shen-Hsi SH   Kalkan Tüzer T   Morissroe Claire C   Marks Hendrik H   Stunnenberg Hendrik H   Smith Austin A   Sharrocks Andrew D AD  

Cell reports 20140612 6

Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of the cell types in the body. We know a lot about the complex transcriptional control circuits that maintain the naive pluripotent state under self-renewing conditions but comparatively less about how cells exit from this state in response to differentiation stimuli. Here, we examined the role of Otx2 in this process in mouse ESCs and demonstrate that it plays a leading role in remodeling the gene re  ...[more]

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