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Immunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation

ABSTRACT: To investigate factors that might influence the T-cell suppressive capabilities of mesenchymal stroma cells, T-cell suppressive and non-suppressive mesenchymal stroma cells were compared. Immunosuppressive capabilities of MSCs was determined via T-cell proliferation assay.

ORGANISM(S): Homo sapiens

SUBMITTER: Philipp Nold 

PROVIDER: E-MTAB-2396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Immunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation.

Nold Philipp P   Hackstein Holger H   Riedlinger Tabea T   Kasper Cornelia C   Neumann Anne A   Mernberger Marco M   Fölsch Christian C   Schmitt Jan J   Fuchs-Winkelmann Susanne S   Barckhausen Christina C   Killer Madeleine M   Neubauer Andreas A   Brendel Cornelia C  

Cytotherapy 20141121 2

<h4>Background aims</h4>The discovery of regenerative and immunosuppressive capacities of mesenchymal stromal cells (MSCs) raises hope for patients with tissue-damaging or severe, treatment-refractory autoimmune disorders. We previously presented a method to expand human MSCs in a bioreactor under standardized Good Manufacturing Practice conditions. Now we characterized the impact of critical treatment conditions on MSCs with respect to immunosuppressive capabilities and proliferation.<h4>Method  ...[more]

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