Unknown,Transcriptomics,Genomics,Proteomics

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Oncogenic Myc levels activate and repress specific genes to form characteristic expression profiles in human tumors

ABSTRACT: Myc was depleted in HeLa cells (ATCC CRL-1934) with an shRNA and the resulting expression profile changes mapped via microarrays. This study is the equivalent of E-MTAB-1524 . E-MTAB-1524 has been replaced by E-MTAB-1886.

ORGANISM(S): Homo sapiens

SUBMITTER: Susanne Walz 

PROVIDER: E-MTAB-1886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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In mammalian cells, the MYC oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the expression of virtually all genes. In contrast, MYC-driven tumour cells differ from normal cells in the expression of specific sets of up- and downregulated genes that have considerable prognostic value. To understand this discrepancy, we studied the consequences of inducible expression and depletion of MYC in human cells and murine tumour  ...[more]

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