Ontology highlight
ABSTRACT:
ORGANISM(S): Homo_sapiens
SUBMITTER: Stefanie Peter
PROVIDER: E-MTAB-1890 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
EMBO molecular medicine 20141201 12
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF-BP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorectal cancer cells in culture and in orthotopic xenograft models. Using high-throughput screening, we identify small molecule inhibitors of HUWE1, which inhibit MYC-dependent transactivation in colorectal ...[more]