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Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

ABSTRACT: Investigating the response of long non-coding RNA expression to LPS stimulation in human monocytes. This experiment is related to the microarray study E-MTAB-2408.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Ilott

PROVIDER: E-MTAB-2399 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes.

IIott Nicholas E NE Heward James A JA Roux Benoit B Tsitsiou Eleni E Fenwick Peter S PS Lenzi Luca L Goodhead Ian I Hertz-Fowler Christiane C Heger Andreas A Hall Neil N Donnelly Louise E LE Sims David D Lindsay Mark A MA

Nature communications 20140609

Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence against infection, is largely unexplored. To address this issue, here we characterize the long non-coding RNA transcriptome in primary human monocytes using RNA sequencing. We identify 76 enhancer RNAs (eRNAs), 40 canonical lncRNAs, 65 antisense lncRNAs and 35 regions of bidirectional transcription (RB ...[more]

PMID: 24909122

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Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes - microarray study

Project description:Investigating the response of long non-coding RNA expression to LPS stimulation in human monocytes. This experiment is related to the RNA-seq study E-MTAB-2399.

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2017-08-01 | E-MTAB-4501 | biostudies-arrayexpress

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Combining transcriptome and proteome analysis to identify and characterize the RpoS regulon in Pseudomonas fluorescens

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2014-05-30 | E-MTAB-2079 | biostudies-arrayexpress

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