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Analysis of Two Component Systems in Group B Streptococcus

ABSTRACT: Group B Streptococcus (GBS), in its transition from commensal to pathogen, will encounter diverse host environments and thus require coordinately controlling its transcriptional responses to these changes. This work was aimed at better understanding the role of two component signal transduction systems (TCS) in GBS pathophysiology through a systematic screening procedure. We first performed a complete inventory and sensory mechanism classification of all putative GBS TCS by genomic analysis. Five TCS were further investigated by the generation of knock-out strains from WT strain CJB111, and in vitro transcriptome analysis identified genes regulated by these systems.

ORGANISM(S): Streptococcus agalactiae

SUBMITTER: Alessandro Muzzi 

PROVIDER: E-MTAB-2423 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness.

Faralla Cristina C   Metruccio Matteo M MM   De Chiara Matteo M   Mu Rong R   Patras Kathryn A KA   Muzzi Alessandro A   Grandi Guido G   Margarit Immaculada I   Doran Kelly S KS   Janulczyk Robert R  

mBio 20140520 3

<h4>Unlabelled</h4>Group B Streptococcus (GBS), in the transition from commensal organisms to pathogens, will encounter diverse host environments and, thus, require coordinated control of the transcriptional responses to these changes. This work was aimed at better understanding the role of two-component signal transduction systems (TCS) in GBS pathophysiology through a systematic screening procedure. We first performed a complete inventory and sensory mechanism classification of all putative GB  ...[more]

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