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Group B meningococcus (MC58) - Wild type and delta nadR strains grown at mid log in GC broth

ABSTRACT: Analysis of global gene transcription profile of wild type MC58 and nadR deletion mutant strains grown in GC until mid log phase

ORGANISM(S): Neisseria meningitidis

SUBMITTER: Luca Fagnocchi

PROVIDER: E-MTAB-803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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In the NadR regulon, adhesins and diverse meningococcal functions are regulated in response to signals in human saliva.

Fagnocchi Luca L Pigozzi Eva E Scarlato Vincenzo V Delany Isabel I

Journal of bacteriology 20111111 2

The Neisseria meningitidis regulator NadR was shown to repress expression of the NadA adhesin and play a major role in NadA phase-variable expression. In this study, we identified through microarray analysis over 30 genes coregulated with nadA in the NadR mutant and defined members of the NadR regulon through in vitro DNA-binding assays. Two distinct types of promoter architectures (I and II) were identified for NadR targets, differing in both the number and position of NadR-binding sites. All N ...[more]

PMID: 22081399

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| S-EPMC5515891 | biostudies-literature