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Role of IL-17RA in the development of parasite-specific cytotoxic responses during Trypanosoma cruzi infection

ABSTRACT: IL-17RA knockout mice presented increased tissue parasitism during T. cruzi infection that correlated with a reduced frequency of parasite-specific CD8+ T cells. Parasite-specific CD8+ T cells from KO mice showed similar proliferation rate but increased mortality and an exhausted phenotype when compared to WT counterparts. We hypothesize that during T. cruzi infection, IL-17RA signaling in CD8+ T cells is required for the regulation of a transcriptional program that prevents accelerated mortality and exhaustion and sustain the development of robust cytotoxic response required for efficient parasite control.

ORGANISM(S): Mus musculus

SUBMITTER: Eliane Piaggio

PROVIDER: E-MTAB-2438 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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