Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Joseph Lotem
PROVIDER: E-GEOD-50121 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20131113 11
The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3(-/-) primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and IL-2-activated states. Runx3-bound genomic regions in both ...[more]