Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Aurore Saudemont
PROVIDER: E-MTAB-2531 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Escobedo-Cousin Michelle M Jackson Nicola N Laza-Briviesca Raquel R Ariza-McNaughton Linda L Luevano Martha M Derniame Sophie S Querol Sergio S Blundell Michael M Thrasher Adrian A Soria Bernat B Cooper Nichola N Bonnet Dominique D Madrigal Alejandro A Saudemont Aurore A
PloS one 20151014 10
Cord blood (CB) is increasingly used as a source of hematopoietic stem cells (HSC) for transplantation. Low incidence and severity of graft-versus-host disease (GvHD) and a robust graft-versus-leukemia (GvL) effect are observed following CB transplantation (CBT). However, its main disadvantages are a limited number of HSC per unit, delayed immune reconstitution and a higher incidence of infection. Unmanipulated grafts contain accessory cells that may facilitate HSC engraftment. Therefore, the ef ...[more]