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Ionizing radiation exposure of developing mouse brain and cultured neurons

ABSTRACT: The mammalian brain is especially sensitive to ionizing radiation during development, as shown by the increased occurrence of mental retardation and small head size in children who were in utero exposed to ionizing radiation after the atomic bombings of Hiroshima and Nagasaki. These effects of prenatal irradiation can be mimicked by irradiation of mouse embryos during the organogenesis period. In order to better understand the early effects of ionizing radiation on the embryonic brain and immature neurons, we performed a microarray analysis on brains from mice irradiated with different doses at E11 and E14, as well as primary cortical neuron cultures after 14 h in vitro. RNA was extracted at either 2 h (brains) or 6 h (neurons) post-irradiation.

ORGANISM(S): Mus musculus

SUBMITTER: Roel Quintens

PROVIDER: E-MTAB-2632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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