Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Strand-specific RNA-seq of nine cow tissues


ABSTRACT: This experiment is contains cow organism part samples and strand-specific RNA-seq data from experiment E-GEOD-41637 (https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41637/), which aimed at assessing tissue-specific transcriptome variation across mammals, with chicken used as an outgroup in evolutionary analyses. Each organism part was sourced from three different animals as biological replicates. This data set was originally submitted to NCBI Gene Expression Omnibus under accession number GSE41637 (http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE41637) and later imported to ArrayExpress as E-GEOD-41637.

ORGANISM(S): Bos taurus

SUBMITTER: Jason Merkin 

PROVIDER: E-MTAB-2798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.

Merkin Jason J   Russell Caitlin C   Chen Ping P   Burge Christopher B CB  

Science (New York, N.Y.) 20121201 6114


Most mammalian genes produce multiple distinct messenger RNAs through alternative splicing, but the extent of splicing conservation is not clear. To assess tissue-specific transcriptome variation across mammals, we sequenced complementary DNA from nine tissues from four mammals and one bird in biological triplicate, at unprecedented depth. We find that while tissue-specific gene expression programs are largely conserved, alternative splicing is well conserved in only a subset of tissues and is f  ...[more]

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