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Strand-specific RNA-seq of nine rhesus macaque tissues

ABSTRACT: This experiment is contains rhesus macaque organism part samples and strand-specific RNA-seq data from experiment E-GEOD-41637 (https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41637/), which aimed at assessing tissue-specific transcriptome variation across mammals, with chicken used as an outgroup in evolutionary analyses. Each organism part was sourced from three different animals as biological replicates. This data set was originally submitted to NCBI Gene Expression Omnibus under accession number GSE41637 (http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE41637) and later imported to ArrayExpress as E-GEOD-41637.

ORGANISM(S): Macaca mulatta

SUBMITTER: Jason Merkin

PROVIDER: E-MTAB-2799 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.

Merkin Jason J Russell Caitlin C Chen Ping P Burge Christopher B CB

Science (New York, N.Y.) 20121201 6114

Most mammalian genes produce multiple distinct messenger RNAs through alternative splicing, but the extent of splicing conservation is not clear. To assess tissue-specific transcriptome variation across mammals, we sequenced complementary DNA from nine tissues from four mammals and one bird in biological triplicate, at unprecedented depth. We find that while tissue-specific gene expression programs are largely conserved, alternative splicing is well conserved in only a subset of tissues and is f ...[more]

PMID: 23258891

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