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Restrictive and extensively self-renewing erythroblast

ABSTRACT: Transcription profiles of self renewing erythroblast cultures isolated from both the restricted and extensively self-renewing phases of growth. The samples are paired.

ORGANISM(S): Mus musculus

SUBMITTER: Paul Kingsley

PROVIDER: E-MTAB-3112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.

England Samantha J SJ McGrath Kathleen E KE Frame Jenna M JM Palis James J

Blood 20101202 9

In the hematopoietic hierarchy, only stem cells are thought to be capable of long-term self-renewal. Erythroid progenitors derived from fetal or adult mammalian hematopoietic tissues are capable of short-term, or restricted (10(2)- to 10(5)-fold), ex vivo expansion in the presence of erythropoietin, stem cell factor, and dexamethasone. Here, we report that primary erythroid precursors derived from early mouse embryos are capable of extensive (10(6)- to 10(60)-fold) ex vivo proliferation. These c ...[more]

PMID: 21127173

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