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Thy-1 Expression Enriches for Self-Renewing Murine MRUs

ABSTRACT: Thy-1 Expression Enriches for Self-Renewing Murine MRUs

PROVIDER: PRJNA352996 | ENA |

REPOSITORIES: ENA

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Project description:Thy-1 Expression Enriches for Self-Renewing Murine MRUs [BL6]

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Thy-1 Expression Enriches for Self-Renewing Murine MRUs [FVB]

Project description:Enriched cell populations from murine mammary epithelium were isolated by FACS and subjected to Affymetrix Mouse 430 2.0 microarray analysis.

2016-11-10 | GSE89719 | GEO

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Restrictive and extensively self-renewing erythroblast

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Thy-1 Expression Enriches for Self-Renewing Murine MRUs

Project description:This SuperSeries is composed of the SubSeries listed below.

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Bone marrow-derived non-transformed murine macrophages with an unlimited self-renewing ability

Project description:Tissue macrophages derive from bone marrow monocytes, and recent studies using mice have revealed that they also derive from yolk sac precursors or fetal liver monocytes. However, embryo-derived macrophages are supposed to be more important to maintain tissue macrophage pool because they can self-renew. Here, we show that adult bone marrow-derived macrophages (MDM) also retain the ability of self-renewal. Where they were readily obtained by a long-term culture: mouse bone marrow cells were cultured with macrophage colony-stimulating factor (M-CSF). After several passages, most MDM died owing to their limited life span with survival and expansion of self-renewing macrophages resided in a small fraction. Self-renewing macrophages were not tumorigenic, but proliferate for a long period in almost unlimited numbers. Despite being distinct from MDM, they were phenotypically and functionally differentiated macrophages, and could differentiate into dendritic cells or osteoclasts. Moreover, Krüppel-like Factor 2 (KLF2) involved in self-renewal of embryonic stem cells, was markedly up-regulated by M-CSF-stimulation in self-renewing macrophages, which was accompanied with a gradual down-regulation of MafB, a suppressor of KLF2 expression. Importantly, knockdown of KLF2 as well as c-Myc caused cell cycle arrest, apoptosis, and diminished cell growth. Our culture method results suggest the presence of precursor(s) for self-renewing macrophages in adult bone marrow that can be used to describe discrepancy of adult- and embryo-derived macrophages. Microarray data from both monocyte-derived and bone marrow-derived mouse macrophages are used to detail the global gene expression profile underlying phenotype, function and self-renewal capacity in order to unravel difference/similarity in phenotype/function and mechanism/degree of self-renewal between the two distinct macrophages.

2019-12-27 | GSE142619 | GEO

Bone marrow-derived non-transformed murine macrophages with an unlimited self-renewing ability

Project description:Bone marrow-derived non-transformed murine macrophages with an unlimited self-renewing ability

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SCL and LMO1 reprogram thymocytes into self-renewing cells.

Project description:The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3Îµ-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.

2015-11-05 | E-GEOD-74659 | biostudies-arrayexpress

SCL and LMO1 reprogram thymocytes into self-renewing cells.

2015-11-05 | GSE74659 | GEO