Dataset Information
Deregulation of PPAR-beta/delta target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - RNAseq
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer II, Illumina HiSeq 1500
ORGANISM(S): Homo sapiens
SUBMITTER: Florian Finkernagel
PROVIDER: E-MTAB-3167 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.
Oncotarget 20150501 15
The nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a lipid ligand-inducible transcription factor associated with macrophage polarization. However, its function in tumor-associated macrophages (TAMs) has not been investigated to date. Here, we report the PPARβ/δ-regulated transcriptome and cistrome for TAMs from ovarian carcinoma patients. Comparison with monocyte-derived macrophages shows that the vast majority of direct PPARβ/δ target genes are upregulated in TAMs ...[more]
