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KSHV-vGPCR induces genomic instability in a miR-34a-dependent manner

ABSTRACT: Cell lines of a vGPCR-driven tumor model have been compared to identify KSHV-vGPCR-dependent mechanisms of tumor progression. Cell lines include two biological replicates of a vGPCR-transformed tumor cell line (vGPCR-TC#1+#2) generated by passaging a vGPCR-BALB/c-3T3 cell line (also included) through athymic nude and BALB/c mice. A vGPCR-knockdown tumor cell line (derived from vGPCR-TC#1 generated by lentiviral knockdown) and a GFP-transduced control BALB/c-3T3 cell line are included as well. Data also include a vGPCR-TC#1-derived cell line were miR-34a-5p was knocked down using a Tough Decoy RNA, called TuDmiR-34a-TC#1. Additionally, two miR-34a overexpressing cell lines have been generated derived from the parental vGPCR-3T3 cells and the tumor cell line vGPCR-TC#2 named miR-34a-vGPCR-3T3 respectively miR-34a-vGPCR-TC#2.

ORGANISM(S): Mus musculus

SUBMITTER: Claudia Krause

PROVIDER: E-MTAB-3393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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