Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: edoardo missiaglia
PROVIDER: E-MTAB-3580 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hingorani Pooja P Missiaglia Edoardo E Shipley Janet J Anderson James R JR Triche Timothy J TJ Delorenzi Mauro M Gastier-Foster Julie J Wing Michele M Hawkins Douglas S DS Skapek Stephen X SX
Clinical cancer research : an official journal of the American Association for Cancer Research 20151001 20
<h4>Purpose</h4>Pediatric rhabdomyosarcoma (RMS) has two common histologic subtypes: embryonal (ERMS) and alveolar (ARMS). PAX-FOXO1 fusion gene status is a more reliable prognostic marker than alveolar histology, whereas fusion gene-negative (FN) ARMS patients are clinically similar to ERMS patients. A five-gene expression signature (MG5) previously identified two diverse risk groups within the fusion gene-negative RMS (FN-RMS) patients, but this has not been independently validated. The goal o ...[more]