Leptin as a Mediator of Tumor-Stromal Interactions Promotes Breast Cancer Stem Cell Activity
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ABSTRACT: Breast cancer stem cells (BCSCs) play crucial roles in tumor initiation, metastasis and resistance to anticancer therapies. These cells rely for their properties on complex interactions with the tumor microenvironment through networks of cytokines and growth factors. In this study, we investigated how leptin, as a mediator of tumor-stromal interactions, may affect BCSC activity using breast cancer cell lines and patient-derived samples. Microarray analyses revealed a similar expression profile of genes involved in stem cell biology in mammosphere cells treated with stromal cell-CM and leptin.
ORGANISM(S): Homo sapiens
SUBMITTER: Angela Cordella
PROVIDER: E-MTAB-3641 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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