Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Variation and genetic control of chromatin architecture in humans (ChIPseq)

ABSTRACT: This data set comprises population (47 samples) measurements of transcription factor DNA binding (PU.1 and RPB2) and histone modification (H3K27ac, H3K4me1 and H3k4me3) levels for a subset of the 1000 Genomes Project CEPH samples. This data was generated as part of the following study: - Population Variation and Genetic Control of Modular Chromatin Architecture in Humans. Cell. 2015 Aug 27;162(5):1039-50. doi: 10.1016/j.cell.2015.08.001. Epub 2015 Aug 20. An additional set of 111 samples from the 1000 Genomes Project (GBR and TSI populations) were also assayed for three histone modifications (H3K27ac, H3K4me1 and H3k4me3). This data was generated as part of the following study: - Chromatin 3D interactions mediate genetic effects on regulatory networks.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Emmanouil Dermitzakis 

PROVIDER: E-MTAB-3657 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase II, and gene expression in lymphoblastoid cell lines from 47 whole-genome sequenced individuals. We observed that distinct cis-regulatory elements exhibit coordinated chromatin variation across individuals in the form of variable chromatin modu  ...[more]

Similar Datasets

Transcriptomics Variation and genetic control of chromatin architecture in humans (RNAseq)
2016-05-27 | E-MTAB-3656 | biostudies-arrayexpress
Genomics Genome-wide maps of chromatin state in human iPSC derived Cardiomyocytes with 2N and 4N DNA content.
2021-05-06 | GSE130285 | GEO
Genomics Transcriptional Regulationand Chromatin Dynamics in Human Epithelial Cell Differentiation (ChIP-seq)
2016-04-04 | E-GEOD-64298 | biostudies-arrayexpress
Transcriptomics Enhancer chromatin signatures predict Smad2/3 binding in Xenopus
2014-09-17 | E-GEOD-56000 | biostudies-arrayexpress
Genomics Genome-wide map of 4 histone modifications and PolII in iPSC-derived human cardiomyocytes
2016-02-22 | E-GEOD-77267 | biostudies-arrayexpress
Genomics Epigenomic landscape during organ formation in human early embryos
2016-07-05 | E-GEOD-63634 | biostudies-arrayexpress
Genomics Transcriptional Regulationand Chromatin Dynamics in Human Epithelial Cell Differentiation (ChIP-seq)
2016-04-04 | GSE64298 | GEO
Transcriptomics small RNA-sequencing of 452 lymphoblastoid cell lines from the 1000 Genomes
2012-11-06 | E-GEUV-2 | biostudies-arrayexpress
Genomics H3K4me1 distribution at promoters predicts the poised epigenetic state
2020-04-05 | GSE145225 | GEO
Genomics Determine the genome-wide localization of histone and histone marks in different stages of D. discoideum
2021-04-21 | GSE137599 | GEO