Unknown,Transcriptomics,Genomics,Proteomics

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Effect of deferasirox and deferoxamine treatment on hematopoietic stem cells gene expression

ABSTRACT: To investigate new molecular pathways affected by deferasirox or deferoxamine able to explain hematopoiesis restoration

ORGANISM(S): Homo sapiens

SUBMITTER: Vittorio Simeon 

PROVIDER: E-MTAB-6658 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells.

Tataranni Tiziana T   Mazzoccoli Carmela C   Agriesti Francesca F   De Luca Luciana L   Laurenzana Ilaria I   Simeon Vittorio V   Ruggieri Vitalba V   Pacelli Consiglia C   Della Sala Gerardo G   Musto Pellegrino P   Capitanio Nazzareno N   Piccoli Claudia C  

Stem cell research & therapy 20190613 1

<h4>Background</h4>Administration of the iron chelator deferasirox (DFX) in transfusion-dependent patients occasionally results in haematopoiesis recovery by a mechanism remaining elusive. This study aimed to investigate at a molecular level a general mechanism underlying DFX beneficial effects on haematopoiesis, both in healthy and pathological conditions.<h4>Methods</h4>Human healthy haematopoietic stem/progenitor cells (HS/PCs) and three leukemia cell lines were treated with DFX. N-Acetyl cys  ...[more]

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