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Genome-wide binding analysis of the transcriptional regulator TrmBL1 in Pyrococcus furiosus

ABSTRACT: The transcriptional regulator TrmBL1 from the hyperthermophilic euryarchaeon Pyrococcus furiosus functions as repressor as well as activator of genes encoding enzymes mainly involved in sugar uptake, glykolysis and gluconeogenesis. The aim of this study was to explore the genome-wide binding sites of TrmBL1 in Pyrococus furiosus by ChIP-seq in vivo. Two different growth conditions were tested. Pyrococcus furiosus was cultured on pyruvate to induce gluconeogenic growth and on starch to induce glycolytic growth.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Pyrococcus furiosus DSM 3638

SUBMITTER: Winfried Hausner

PROVIDER: E-MTAB-3959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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