Unknown,Transcriptomics,Genomics,Proteomics

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Strand-specific RNA-seq of 13 human tissues from Michael Snyder's lab for the ENCODE project

ABSTRACT: This ArrayExpress experiment contains RNA-seq data from human tissues, generated by Michael Snyder's lab at Stanford University as part of the ENCODE project ( https://www.encodeproject.org/search/?type=Experiment ). Sample information was obtained from the ENCODE data coordination center and protocol information was obtained from the associated publication in PNAS (Lin et al., 2014, PubMed ID 25413365). All samples, except for the ovary, were sequenced with technical replicates. The second technical replicate was performed in May 2015 and was not part of the original Lin et al. 2014 publication. Technical replicates are marked in the “Comment[technical replicate group]” column of sample-data-relationship format (SDRF) file for this record.

ORGANISM(S): Homo sapiens

SUBMITTER: ENCODE Data Coordination Center 

PROVIDER: E-MTAB-4344 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparison of the transcriptional landscapes between human and mouse tissues.

Lin Shin S   Lin Yiing Y   Nery Joseph R JR   Urich Mark A MA   Breschi Alessandra A   Davis Carrie A CA   Dobin Alexander A   Zaleski Christopher C   Beer Michael A MA   Chapman William C WC   Gingeras Thomas R TR   Ecker Joseph R JR   Snyder Michael P MP  

Proceedings of the National Academy of Sciences of the United States of America 20141120 48

Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and examined the similarities and differences in the transcriptome for both protein-coding and -noncoding transcripts. Although commonalities are evident in the expression of tissue-specific genes between the tw  ...[more]

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