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18 treatment refractory Diffuse Large B-Cell Lymphomas

ABSTRACT: Frozen biopsies collected at diagnosis from 18 DLBCLs were analyzed to find copy number events that could predict the relapse. Hybridizations were performed against a common DNA pool.

ORGANISM(S): Homo sapiens

SUBMITTER: Sylvain Mareschal

PROVIDER: E-MTAB-4496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Detection of somatic quantitative genetic alterations by multiplex polymerase chain reaction for the prediction of outcome in diffuse large B-cell lymphomas.

Jardin Fabrice F Ruminy Philippe P Kerckaert Jean-Pierre JP Parmentier Françoise F Picquenot Jean-Michel JM Quief Sabine S Villenet Céline C Buchonnet Gérard G Tosi Mario M Frebourg Thierry T Bastard Christian C Tilly Hervé H

Haematologica 20080220 4

<h4>Background</h4>Genomic gains and losses play a crucial role in the development of diffuse large B-cell lymphomas. High resolution array comparative genomic hybridization provides a comprehensive view of these genomic imbalances but is not routinely applicable. We developed a polymerase chain reaction assay to provide information regarding gains or losses of relevant genes and prognosis in diffuse large B-cell lymphomas.<h4>Design and methods</h4>Two polymerase chain reaction assays (multiple ...[more]

PMID: 18287131

Publication: 1/2

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