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Twist, Snail and Zeb1 targets in the context of TrkB

ABSTRACT: RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1

ORGANISM(S): Rattus norvegicus

SUBMITTER: Iris de Rink

PROVIDER: E-MTAB-456 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis.

Smit M A MA Peeper D S DS

Oncogene 20110411 35

Anoikis (detachment-induced apoptosis) prevents the survival of cells at inappropriate sites of the body and can therefore act as a barrier to metastasis. In a function-based genome-wide screen, we have previously identified the neurotrophic tyrosine kinase receptor TrkB as a potent suppressor of anoikis. Consistently, activated TrkB oncogenically transforms non-malignant epithelial cells and causes them to invade and produce metastatic tumors in vivo. Overexpression of activated TrkB also resul ...[more]

PMID: 21478908

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