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Cell surface markers that distinguish human beta cells and alpha cells

ABSTRACT: The goal of this experiment is to determine cell surface markers that are present in human beta cells or alpha cells but not both. Cells from human islets were FACS sorted and prepared as matched pairs of beta and alpha cells preparations.

ORGANISM(S): Homo sapiens

SUBMITTER: Markus Grompe

PROVIDER: E-MTAB-459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice.

Dorrell Craig C Erker Laura L Schug Jonathan J Kopp Janel L JL Canaday Pamela S PS Fox Alan J AJ Smirnova Olga O Duncan Andrew W AW Finegold Milton J MJ Sander Maike M Kaestner Klaus H KH Grompe Markus M

Genes & development 20110601 11

The molecular identification of adult hepatic stem/progenitor cells has been hampered by the lack of truly specific markers. To isolate putative adult liver progenitor cells, we used cell surface-marking antibodies, including MIC1-1C3, to isolate subpopulations of liver cells from normal adult mice or those undergoing an oval cell response and tested their capacity to form bilineage colonies in vitro. Robust clonogenic activity was found to be restricted to a subset of biliary duct cells antigen ...[more]

PMID: 21632826

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