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The genome-scale DNA-binding profile of BarR

ABSTRACT: The Leucine-responsive Regulatory Protein (Lrp) family is a widespread family of regulatory transcription factors in prokaryotes. BarR is an Lrp-like transcription factor in the model archaeon Sulfolobus acidocaldarius that activates the expression of a -alanine aminotransferase gene, which is involved in -alanine degradation. In contrast to classical Lrp-like transcription factors, BarR is not responsive to any of the -amino acids but interacts specifically with -alanine. Besides the juxtaposed -alanine aminotransferase gene, other regulatory targets of BarR have not yet been identified although -alanine is the precursor of coenzyme A and thus an important central metabolite. The aim of this study is to extend the knowledge of the DNA-binding characteristics of BarR and of its corresponding regulon from a local to a genome-wide perspective.

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): Sulfolobus acidocaldarius DSM 639

SUBMITTER: kun wang

PROVIDER: E-MTAB-4615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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