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MicroRNA profiling by arrray of unilaterial and bilateral retinoblastoma tumours from enucleated patients with no chemotherapy history

ABSTRACT: Retinoblastoma (Rb) is the most common intraocular tumor in childhood and represent a very robust model about hereditary develop for cancer. We believe that miRNome expression may give clues to understanding Rb heterogeneity and to comprehend biological features in order to find new biomarkers for better treatments. We explore 12 Rb tumors from enucleated patients with no chemotherapy history from Children Hospital of Mexico Federico Gomez and Pediatric Hospital Medical Center XXI century by informed parental consent to collaborate with retrospective research. 5 bilateral and 7 unilateral, 4 female and 8 male samples were tailed and labeled with biotin to hybridize in GeneChip miRNA 4.0 Affymetrix array. Chips were washed and scanned 18hrs after hybridization.

ORGANISM(S): Homo sapiens

SUBMITTER: Blanca Elena Castro Magdonel

PROVIDER: E-MTAB-4977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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