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Medicago truncatula strain:Jemalong Transcriptome or Gene expression

ABSTRACT: An intron-spliced hairpin RNA approach was used for the targeted silencing of the MtTdp1α gene encoding the αisoform of tyrosyl-DNA phosphodiesterase 1 in Medicago truncatula Gaertn. Tyrosyl-DNA phosphodiesterase 1, involved in the repair of DNA topoisomerase I-mediated DNA damage, has been poorly investigated in plants. RNA-Seq analysis, carried out in the MtTdp1α-depleted plants, revealed different levels of transcriptional modulation (up- and down-regulation, alternative splicing, activation of alternative promoter) in genes involved in DNA damage sensing, DNA repair, and chromatin remodelling.

INSTRUMENT(S): Illumina HiSeq 1000

ORGANISM(S): Medicago truncatula

SUBMITTER: Alma Balestrazzi 

PROVIDER: E-MTAB-5141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

RNA-Seq analysis discloses early senescence and nucleolar dysfunction triggered by Tdp1α depletion in Medicago truncatula.

Donà Mattia M   Confalonieri Massimo M   Minio Andrea A   Biggiogera Marco M   Buttafava Armando A   Raimondi Elena E   Delledonne Massimo M   Ventura Lorenzo L   Sabatini Maria Elisa ME   Macovei Anca A   Giraffa Giorgio G   Carbonera Daniela D   Balestrazzi Alma A  

Journal of experimental botany 20130306 7

An intron-spliced hairpin RNA approach was used for the targeted silencing of the MtTdp1α gene encoding the αisoform of tyrosyl-DNA phosphodiesterase 1 in Medicago truncatula Gaertn. Tyrosyl-DNA phosphodiesterase 1, involved in the repair of DNA topoisomerase I-mediated DNA damage, has been poorly investigated in plants. RNA-Seq analysis, carried out in the MtTdp1α-depleted plants, revealed different levels of transcriptional modulation (up- and down-regulation, alternative splicing, activation  ...[more]

PMID: 23467834

Publication: 1/2

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