Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies

ABSTRACT: Molecular profiling of effect of TNFα neutralization in contrast to anti-IL-17A or anti-IL-17F treatment for 28 days in lungs of M. tuberculosis infected C57BL/6 mice. Animals were treated once per week (starting day-1) with anti-mouse IL-17A or IL-17F antibodies (20 mg/kg i.p.), anti-mouse TNFα antibody (10 mg/kg), respective isotype control antibodies. Moreover, infected and non-infected TNFα-deficient mice were also analysed. Gene expression data revealed major changes of inflammatory and immune gene expression signatures 4 weeks post-infection (including host-pathogen interactions, macrophage recruitment, activation and polarization, host-anti-mycobacterial activities, immunomodulatory responses and extracellular matrix metallopeptidases) after TNFα blockade, while IL-17A or IL-17F neutralization elicited only mild changes of few genes without impaired host resistance four weeks after M. tuberculosis infection.

ORGANISM(S): Mus musculus

SUBMITTER: Elaine Tritto 

PROVIDER: E-MTAB-5218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization.

Segueni Noria N   Tritto Elaine E   Bourigault Marie-Laure ML   Rose Stéphanie S   Erard François F   Le Bert Marc M   Jacobs Muazzam M   Di Padova Franco F   Stiehl Daniel P DP   Moulin Pierre P   Brees Dominique D   Chibout Salah-Dine SD   Ryffel Bernhard B   Kammüller Michael M   Quesniaux Valerie F VF  

Scientific reports 20161117

Antibodies targeting IL-17A or its receptor IL-17RA show unprecedented efficacy in the treatment of autoimmune diseases such as psoriasis. These therapies, by neutralizing critical mediators of immunity, may increase susceptibility to infections. Here, we compared the effect of antibodies neutralizing IL-17A, IL-17F or TNFα on murine host responses to Mycobacterium tuberculosis infection by evaluating lung transcriptomic, microbiological and histological analyses. Coinciding with a significant i  ...[more]

Similar Datasets

Models,Multiomics Corral2021 - Interplay between SMAD2 and STAT5A regulating IL-17A/F expression in Th cells.
2021-04-06 | MODEL2101150001 | BioModels
Transcriptomics Genome-wide characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice
2014-02-20 | E-GEOD-55183 | biostudies-arrayexpress
Transcriptomics RNA sequencing of IL-17A and IL-17F producing cells
2023-11-20 | GSE189230 | GEO
Transcriptomics The expression profiles of extracellular matrix-related genes in the presence or absence of IL-17A or -17F as measured with the PCR array in systemic sclerosis (SSc) dermal fibroblasts
2012-01-01 | E-GEOD-33581 | biostudies-arrayexpress
Genomics IL-17A and IL-17F producing cells
| PRJNA782122 | ENA
Genomics ChIP sequencing of IL-17A and IL-17F producing cells
2023-11-20 | GSE189231 | GEO
Transcriptomics The expression profiles of extracellular matrix-related genes in the presence or absence of IL-17A or -17F as measured with the PCR array in systemic sclerosis (SSc) dermal fibroblasts
2012-01-01 | GSE33581 | GEO
Transcriptomics Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro
2021-06-02 | GSE171952 | GEO
Transcriptomics IL-17 cytokines preferentially act on naïve CD4+ T cells
2022-10-03 | GSE159406 | GEO
Genomics ChIP sequencing of IL-17A and IL-17F producing cells
| PRJNA782123 | ENA