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RNA sequencing of IL-17A and IL-17F producing cells

ABSTRACT: IL-17A has emerged as a pivotal driver of tissue pathology in many immune-mediated inflammatory diseases. Despite sharing 50% sequence homology and the same signalling pathway, the role of IL-17F remains less clear. RNA sequencing of human IL-17 popualtions isolated using a cytokine capture technique identified clear transcriptional differences in IL-17A and IL-17F producing cells, with IL-17A producing cells showing enrichment for cytokine signaling and IL-17F producing cells showing enrichment for cellular replication.

ORGANISM(S): Homo sapiens

PROVIDER: GSE189230 | GEO | 2023/11/20

REPOSITORIES: GEO

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