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Gene expression profiling of Hox-driven AML overexpressing JMJD1C

ABSTRACT: JMJD1C, a Jumonji C (JmjC) domain-containing histone demethylase, has been reported as a direct cofactor of oncogenic transcription factor HOXA9. To identify JMJD1C downstream effectors, we performed a genome-wide gene expression profiling experiment. Our microarray analysis identified a new role for JMJD1C in regulating a cancer metabolic program in HOX-driven AML. GFP+ HOXA9/MEIS1-mediated pre-leukemic stem cells were transduced with retroviruses carrying JMJD1C or empty vector for the microarray experiment. Each group has 4 samples.

ORGANISM(S): Mus musculus

SUBMITTER: Jenny Wang

PROVIDER: E-MTAB-5760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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