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Transcription profiling by array of decidual CD8+ CCR7-CD45RA- Effector-Memory T cells

ABSTRACT: To understand the regulation of cytotoxicity by decidual CD8+ T cells (CD8+ dT) at the maternal-fetal interface, gene expression analysis of CCR7-CD45RA- effector-memory CD8+ T cells isolated from peripheral blood of unrelated healthy controls and decidual tissue from first trimester (6-12 weeks) and term (>37 weeks) pregnancy was performed. Furthermore, first trimester decidual effector-memory CD8+ T cells were stimulated with anti-CD3/CD28 in the presence of IL-2 for 12 hours or 72 hours. RNA was isolated and gene expression profiles were generated by employing Affymetrix HG_U133_Plus 2 arrays on the Affymetrix Geneatlas system.

ORGANISM(S): Homo sapiens

SUBMITTER: Tamara Tilburgs

PROVIDER: E-MTAB-5890 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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