Unknown,Transcriptomics,Genomics,Proteomics

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Contribution of the Hog1 SAPK to nitrosative stress response in Candida albicans.

ABSTRACT: RNA sequencing was performed on Candida albicans wild type cells (JC50) grown to exponential phase on YPD , YPD plus Nitrosative Stress 2.5mM DPTA NONOate, and compared to exponential Candida albicans hog1 deletion mutant cells grown on on YPD , YPD plus Nitrosative Stress 2.5mM DPTA NONOate. Three independent experiments were performed.

INSTRUMENT(S): Ion Torrent Proton

ORGANISM(S): Candida albicans

SUBMITTER: Lila Stavroula Kastora 

PROVIDER: E-MTAB-5990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs.

Herrero-de-Dios Carmen C   Day Alison M AM   Tillmann Anna T AT   Kastora Stavroula L SL   Stead David D   Salgado Paula S PS   Quinn Janet J   Brown Alistair J P AJP  

mBio 20180327 2

In all eukaryotic kingdoms, mitogen-activated protein kinases (MAPKs) play critical roles in cellular responses to environmental cues. These MAPKs are activated by phosphorylation at highly conserved threonine and tyrosine residues in response to specific inputs, leading to their accumulation in the nucleus and the activation of their downstream targets. A specific MAP kinase can regulate different downstream targets depending on the nature of the input signal, thereby raising a key question: wh  ...[more]

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