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Affymetrix analysis of adult mouse lung exposed to room air or 100% oxygen between postnatal days 0-4

ABSTRACT: It is unclear why preterm birth increases risk of cardiovascular disease later in life. Studies in mice indicate excess oxygen used to treat preterm infants causes pulmonary hypertension, cardiac failure, and shortens lifespan. We previously reported neonatal hyperoxia causes pulmonary hypertension in aged mice as defined pathologically by pulmonary capillary rarefaction, dilation of pulmonary arterioles and veins, right ventricular hypertrophy, and reduced lifespan. Here, affymetrix gene arrays were used to identify early transcriptional changes in lungs of young adult mice exposed to room air or 100% oxygen between postnatal days 0-4.

ORGANISM(S): Mus musculus

SUBMITTER: Michael O'Reilly

PROVIDER: E-MTAB-6074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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