Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ethan Cohen
PROVIDER: E-MTAB-9008 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
JCI insight 20210308 5
Preterm birth increases the risk for pulmonary hypertension and heart failure in adulthood. Oxygen therapy can damage the immature cardiopulmonary system and may be partially responsible for the cardiovascular disease in adults born preterm. We previously showed that exposing newborn mice to hyperoxia causes pulmonary hypertension by 1 year of age that is preceded by a poorly understood loss of pulmonary vein cardiomyocyte proliferation. We now show that hyperoxia also reduces cardiomyocyte prol ...[more]