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MRNA profiling by array for pancreatic ductal adenocarcinoma for clinical application

ABSTRACT: We performed combined gene expression analysis and targeted gene sequencing of 309 consecutive patients from a multicenter consortium.

ORGANISM(S): Homo sapiens

SUBMITTER: Elarouci Nabila

PROVIDER: E-MTAB-6134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features.

Puleo Francesco F Nicolle Rémy R Blum Yuna Y Cros Jérôme J Marisa Laetitia L Demetter Pieter P Quertinmont Eric E Svrcek Magali M Elarouci Nabila N Iovanna Juan J Franchimont Denis D Verset Laurine L Galdon Maria Gomez MG Devière Jacques J de Reyniès Aurélien A Laurent-Puig Pierre P Van Laethem Jean-Luc JL Bachet Jean-Baptiste JB Maréchal Raphaël R

Gastroenterology 20180827 6

<h4>Background & aims</h4>Genomic studies have revealed subtypes of pancreatic ductal adenocarcinoma (PDA) based on their molecular features, but different studies have reported different classification systems. It is a challenge to obtain high-quality, freshly frozen tissue for clinical analysis and determination of PDA subtypes. We aimed to redefine subtypes of PDA using a large number of formalin-fixed and paraffin-embedded PDA samples, which are more amenable to routine clinical evaluation.< ...[more]

PMID: 30165049

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