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Transcription profiling of 57 human bladder carcinoma samples.

ABSTRACT: Transcriptome analysis of 57 bladder carcinomas on Affymetrix HG-U95A and HG-U95Av2 microarrays

ORGANISM(S): Homo sapiens

DISEASE(S): bladder carcinoma

SUBMITTER: Nicolas Stransky

PROVIDER: E-TABM-147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regional copy number-independent deregulation of transcription in cancer.

Stransky Nicolas N Vallot Céline C Reyal Fabien F Bernard-Pierrot Isabelle I de Medina Sixtina Gil Diez SG Segraves Rick R de Rycke Yann Y Elvin Paul P Cassidy Andrew A Spraggon Carolyn C Graham Alexander A Southgate Jennifer J Asselain Bernard B Allory Yves Y Abbou Claude C CC Albertson Donna G DG Thiery Jean Paul JP Chopin Dominique K DK Pinkel Daniel D Radvanyi François F

Nature genetics 20061112 12

Genetic and epigenetic alterations have been identified that lead to transcriptional deregulation in cancers. Genetic mechanisms may affect single genes or regions containing several neighboring genes, as has been shown for DNA copy number changes. It was recently reported that epigenetic suppression of gene expression can also extend to a whole region; this is known as long-range epigenetic silencing. Various techniques are available for identifying regional genetic alterations, but no large-sc ...[more]

PMID: 17099711

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