SNP 6.0 profiling of plasma DNA in breast cancer patients
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): breast carcinoma
SUBMITTER: Kevin Blighe
PROVIDER: E-MTAB-624 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Detection of HER2 amplification in circulating free DNA in patients with breast cancer.
Page K K Hava N N Ward B B Brown J J Guttery D S DS Ruangpratheep C C Blighe K K Sharma A A Walker R A RA Coombes R C RC Shaw J A JA
British journal of cancer 20110322 8
<h4>Background</h4>Human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in 20-25% of breast cancers. This study investigated circulating free DNA (cfDNA) for detection of HER2 gene amplification in patients with breast cancer.<h4>Methods</h4>Circulating free DNA was extracted from plasma of unselected patients with primary breast cancer (22 before surgery and 68 following treatment), 30 metastatic patients and 98 female controls using the QIAamp Blood DNA Mini Kit (Qiag ...[more]
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