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MiR-181b is a biomarker of disease progression in Chronic Lymphocytic Leukemia

ABSTRACT: We studied the value of the microRNAs as a signature for Chronic lymphocytic leukemia (CLL) patients with specific chromosomal abnormalities. We found that MiR-181b is abiomarker of disease progression in Chronic Lymphocytic Leukemia

ORGANISM(S): Homo sapiens

SUBMITTER: Rosa Visone

PROVIDER: E-MTAB-683 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia.

Visone Rosa R Veronese Angelo A Rassenti Laura Z LZ Balatti Veronica V Pearl Dennis K DK Acunzo Mario M Volinia Stefano S Taccioli Cristian C Kipps Thomas J TJ Croce Carlo M CM

Blood 20110602 11

MicroRNAs play a crucial role in chronic lymphocytic leukemia. We investigated whether microRNAs can discriminate patients with a progressive disease from patients with a stable disease. We analyzed microRNA expression on leukemic cells isolated from 358 sequential samples of 114 patients with either stable or progressive disease. We found that during the course of the disease the expression values of miR-181b, the most dysregulated microRNA, decreased in samples of patients with a progressive ( ...[more]

PMID: 21636858

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