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Molecular characterization (biomarkers) and potential targetable signaling pathways of epithelial -mesenchymal transition and its reverse process in breast cancer cells.

ABSTRACT: After 7 days of culture, a sub-population of breast cancer MDAMB231 cells spontaneously detaches the monolayer and starts to grow in suspension, these cells undergo epithelial-mesenchymal transition (EMT), display anoikis resistance and acquire a metastatic phenotype. These cells, in the presence of adherently growing MDAMB231, continue to grow in suspension whereas, seeded in cell-free wells, are able to adhere again and to form E-cadherin positive and vimentin negative new colonies, suggesting the occurrence of mesenchymal-epithelial transition (MET). The expression profiles of these three cell clones (basal, MET and EMT) were investigated by microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Cristina Luceri

PROVIDER: E-MTAB-6954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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